## Haldane's formula in Cannings models: The case of moderately weak selection

23 Jul 2019  ·  Florin Boenkost, Adrián González Casanova, Cornelia Pokalyuk, Anton Wakolbinger ·

We introduce a Cannings model with directional selection via a paintbox construction and establish a strong duality with the line counting process of a new \emph{Cannings ancestral selection graph} in discrete time. This duality also yields a formula for the fixation probability of the beneficial type... Haldane's formula states that for a single selectively advantageous individual in a population of haploid individuals of size $N$ the prob\-ability of fixation is asymptotically (as $N\to \infty$) equal to the selective advantage of haploids $s_N$ divided by half of the offspring variance. For a class of offspring distributions within Kingman attraction we prove this asymptotics for sequences $s_N$ obeying $N^{-1} \ll s_N \ll N^{-1/2}$, which is a regime of "moderately weak selection". It turns out that for $s_N \ll N^{-2/3}$ the Cannings ancestral selection graph is so close to the ancestral selection graph of a Moran model that a suitable coupling argument allows to play the problem back asymptotically to the fixation probability in the Moran model, which can be computed explicitly. read more

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